Sema (GLP-1) (5mg / 10mg)

Semaglutide (Ozempic, Wegovy, Rybelsus) is a prescription GLP-1 medication used for weight loss and weight management, type 2 diabetes treatment, or to reduce the risk of chronic kidney disease and major cardiovascular events in certain patients with type 2 diabetes. Semaglutide (Wegovy) is also used to treat metabolic dysfunction-associated steatohepatitis (MASH), without cirrhosis of the liver.

Semaglutide injections are self-administered once weekly as an injection under the skin, and semaglutide pills are taken once daily.

Semaglutide works by reducing appetite, delaying gastric emptying, increasing insulin release, and lowering the amount of glucagon released. Semaglutide is a GLP-1 receptor agonist that mimics the behavior of the GLP-1 hormone, which is naturally released after eating.

Semaglutide brand names are Ozempic, Rybelsus, and Wegovy, all made by Novo Nordisk. There is no generic semaglutide available. Semaglutide FDA approval was first granted on December 5, 2017, for the brand Ozempic.

Each semaglutide brand or formulation is FDA-approved for specific conditions and patient populations.

What is semaglutide used for?

Semaglutide FDA-approved uses for each brand are Ozempic (type 2 diabetes, reducing cardiovascular event risks, reducing risk of kidney function decline), Wegovy (weight management, reducing cardiovascular event risks, non-cirrhotic MASH), and Rybelsus (type 2 diabetes, reducing cardiovascular event risks).

Semaglutide should be used in addition to a reduced-calorie diet and increased physical activity.

What is Ozempic used for?

Ozempic tablets and injections are FDA-approved in adults for:

• type 2 diabetes to improve blood sugar control
• reducing the risk of a major cardiovascular event (such as heart attack, stroke, or death) in type 2 diabetic patients who are at high risk for these events

Ozempic injection is also FDA-approved in adults for:

• reducing the risk of kidney function decline, kidney failure, and cardiovascular death in patients with type 2 diabetes and chronic kidney disease (CKD)

What is Wegovy used for?

Wegovy tablets and injections are FDA-approved in adults for:

• weight loss and weight management in adults with obesity or adults who are overweight and  have a weight-related medical problem (e.g., blood pressure, type 2 diabetes, or high cholesterol)
• reducing major cardiovascular event risks (such as heart attack, stroke, or death) in adults with established CV disease and either obesity or overweight

Wegovy injection is also FDA-approved for:

• weight loss and weight management patients with obesity who are 12 years and older
• non-cirrhotic metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis), this is an accelerated approval.

What is Rybelsus used for?

Rybelsus oral tablets are FDA-approved in adults for:

• type 2 diabetes in adults to help control blood sugar levels.
• reducing the risk of major cardiovascular events (such as heart attack, stroke, or death) in type 2 diabetic patients with known heart disease.

Also, see Wegovy vs Ozempic: Which is right for you?

Ozempic vs Wegovy vs Rybelsus: Key Differences (Form, Dose, Strength & Uses)

How does semaglutide work?

Semaglutide works by:

• Stimulates insulin production in the pancreas
• Reduces sugar production in the liver
• Slows down digestion, so food stays in the stomach longer
• Decreases appetite and food intake

These combined actions help you feel full longer, eat less, and maintain better control over blood sugar levels. As a result, semaglutide supports weight loss, improves blood sugar management, and helps reduce the risk of cardiovascular events.

Semaglutide’s mechanism of action mimics a natural hormone in the body called GLP-1 (glucagon-like peptide-1), which is released after eating to help regulate appetite and blood sugar levels.

The way semaglutide works for kidney-related risk reduction is not fully understood.

Semaglutide belongs to the drug class called GLP-1 receptor agonists.

What is the cost of semaglutide?

The cost of semaglutide varies depending on your insurance plan and which pharmacy you use.

Refer to our Ozempic price guide page for more information about the Ozempic cost. You may also be eligible for an Ozempic coupon or savings card.

Refer to our Wegovy price guide page for more information about the Wegovy cost. You may also be eligible for a Wegovy coupon or savings card.

Refer to our Rybelsus price guide page for more information about the Rybelsus cost. You may also be eligible for a Rybelsus coupon or savings card.

Semaglutide side effects

Common semaglutide side effects

Common semaglutide side effects may include upset stomach, heartburn, burping, gas, bloating, nausea, vomiting, stomach pain, loss of appetite, diarrhea, constipation, stomach flu symptoms, low blood sugar (in people with type 2 diabetes), headache, dizziness, and tiredness.

Stomach or gastrointestinal side effects are common, but they tend to be mild and clear up in a few weeks and usually will not interfere with long-term treatment. Stomach side effects can be more common with higher doses.

Tips for managing stomach side effects

Following these tips may help you manage stomach semaglutide side effects:

• Eat more slowly
• Eat smaller meals
• Choose more bland, low-fat foods (like crackers, toast, and rice)
• Avoid eating greasy, fried foods or sugar treats
• Eat foods that contain water (like soup or gelatin)
• Do not lie down right after eating
• Drink clear or ice-cold liquids
• If possible, go outside for fresh air if you feel sick to your stomach
• Ryebelsus is not recommended in patients with severe gastroparesis.

Tips for managing low blood sugar levels (hypoglycemia) side effects

• Test blood sugar levels regularly if you are also taking diabetic medicines, including insulin or sulphonylureas (e.g., glibenclamide/glyburide, glipizide, and gliclazide) and when you increase your semaglutide dose.
• Your prescriber might reduce your dose of insulin or sulphonylureas if needed to reduce the risk of hypoglycemia
• Symptoms of low blood sugar levels include:
  • feeling hungry
  • feeling dizzy
  • feeling anxious or irritable
  • sweaty
  • shaky
  • tingling lips
  • heart palpitations
  • feeling tired or weak
  • changes in your vision, such as blurred vision
  • confusion
• Treatment for hypoglycemia
  • Eat or drink something that will raise your blood sugar quickly for example, sugary foods or drinks, including a small glass of fruit juice or sugary fizzy drink (not diet), glucose or dextrose tablets or gel, or sugary candy.
  • Check your blood sugar after 10 to 15 minutes.
  • If your blood sugar is still low, have another sugary drink or snack, and check again after 10 minutes.
  • Once your symptoms have improved, eat a healthy snack or meal that will keep your blood sugar up for longer and prevent another drop in blood sugar.
• Severe hypoglycemia may require a glucagon injection.

Serious semaglutide side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, dizziness, fast heartbeats, difficulty breathing, swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• vision changes;
• unusual mood changes, thoughts about hurting yourself;
• pounding heartbeats or fluttering in your chest;
• a light-headed feeling, like you might pass out;
• signs of a thyroid tumor – swelling or a lump in your neck, trouble swallowing, a hoarse voice, feeling short of breath;
• symptoms of pancreatitis – severe pain in your upper stomach spreading to your back, nausea with or without vomiting, fast heart rate;
• gallbladder problems – upper stomach pain, fever, clay-colored stools, jaundice (yellowing of the skin or eyes);
• low blood sugar – headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery;
• kidney problems – swelling, urinating less, feeling tired or short of breath; or
• stomach flu symptoms – stomach cramps, vomiting, loss of appetite, diarrhea (may be watery or bloody).

MORE INFORMATION

Purity Percentage	99% Purity
Volume	10MG
Bought This Week	5
New	Yes
Sale	Yes